The Green Bay Packers have ruled quarterback Aaron Rodgers out for Sunday night's game against the New England Patriots, Tom Silverstein of the Milwaukee Journal-Sentinel reports.

Rodgers had been listed as "Doubtful" after missing all of this week's practices due to a concussion he sustained during last Sunday's 7-3 loss to the Detroit Lions. It was Rodgers' second concussion of the season.

Third-year quarterback Matt Flynn will make his first NFL start for the 8-5 Packers, who are in must-win mode to keep their playoff hopes alive. Flynn has completed 25-of-46 pass attempts for 246 yards and 2 interceptions in 27 career games, all in a reserve role.

Practice squad quarterback Graham Harrell will be signed to the 53-man roster, with safety Anthony Smith placed on injured reserve.